Basic Information
| ID | DRAMP01849 |
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| Sequence | DSMGAVKLAKLLIDKMKCEVTKAC |
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| Length | 24 |
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| Name | Jindongenin-1a (JD1a; Frogs, amphibians, animals) |
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| Source | Amolops jingdongensis (Chinese torrent frog) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.21816202]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=17 µM), Enterococcus faecalis ATCC29212 (MIC=60 µM), Staphylococcus aureus (IS 10#)(MIC=40 µM);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=10 µM), Enterobacter cloacae ATCC13047 (MIC=40 µM), Klebsiella pneumoniae ATCC700603 (MIC=15 µM), Bacillus pyocyaneus CMCCB1010 (MIC=17 µM), Pseudomonas aeruginosa ATCC27853 (MIC=23 µM), Bacillus dysenteriae (MIC=40 µM);##Yeast: Candida albicans ATCC2002 (MIC=60 µM). |
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| Hemolytic Activity | [Ref.21816202] IC50=150 μM against washed human erythrocytes |
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| Cytotoxicity | [Ref.21816202] Cytotoxicity: the K562 (IC50=46μM)and HT29 mammalian cell lines(IC50=40μM). |
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| N-terminal Modification | Free |
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| C-terminal Modification | Cyclization (Cys18 and Cys24) |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
G3ETQ2 |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 21816202 |
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