Basic Information

IDDRAMP01911
SequenceSIWEGIKNAGKGFLVSILDKVRCKVAGGCNP
Length31
NameBrevinin-2GHc (AMP-4; Frogs, amphibians, animals)
SourceRana guentheri (Gunther's frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Staphylococcus aureus FDA209P (MIC=9.8 µg/ml), Bacillus subtilis ATCC 6633 (MIC>64 µg/ml);##Gram-negative bacteria: Escherichia coli O111 (MIC=19.6 µg/ml), Escherichia coli ATCC 25922 (MIC=9.8 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot A0AEI6
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16979798

Physicochemical Properties

Residues31
SequenceSIWEGIKNAGKGFLVSILDKVRCKVAGGCNP
Molecular Weight3260.829
Grand Average of Hydropathy0.158
Isoelectric Point9.302
Charge at pH 7.42.196
Secondary StructureHelix: 0.323, Turn: 0.323, Sheet: 0.161
Instability Index-0.229
Aromaticity0.065

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