Basic Information
| ID | DRAMP02033 |
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| Sequence | GIMSLFKGVLKTAGKHVAGSLVDQLKCKITGGC |
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| Length | 33 |
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| Name | Brevinin-2TSa (Frogs, amphibians, animals) |
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| Source | Rana tsushimensis (Tsushima brown frog) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.16413829]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 µM), Klebsiella pneumoniae KK3 9904 (MIC=6 µM), Enterobacter cloacae HNTCC 53001 (MIC=6 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=6 µM), Proteus mirabilis ATCC 25933 (MIC>100 µM);##Gram-positive bacteria: Staphylococcus aureus NCTC 8325 (MIC=12.5 µM), Methicillin-resistant Staphylococcus aureus T7/20 (MIC=25 µM), Staphylococcus epidermidis RP62A (MIC=12.5 µM), Enterococcus faecalis ATCC 29212 (MIC=25 µM);##Yeast: Candida albicans ATCC 90028 (MIC=100 µM). |
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| Hemolytic Activity | [Ref.16413829] LD50=100 μM against human erythrocytes |
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| Cytotoxicity | No cytotoxicity information found |
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| N-terminal Modification | Free |
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| C-terminal Modification | Cyclization (Cys27 and Cys33) |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 16413829 |
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