Basic Information

IDDRAMP02070
SequenceSVMGTVKDLLIGAGKSAAQSVLKSLSCKISNDC
Length33
NameBrevinin-2-OW1 (Frogs, amphibians, animals)
SourceOdorrana wuchuanensis (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4.7 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=4.7 µg/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=9.4 µg/ml).##Fungi: Candida albicans (MIC=4.7 µg/ml).
Hemolytic Activity[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 μg/mL.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys27 and Cys33)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues33
SequenceSVMGTVKDLLIGAGKSAAQSVLKSLSCKISNDC
Molecular Weight3324.887
Grand Average of Hydropathy0.388
Isoelectric Point8.801
Charge at pH 7.41.195
Secondary StructureHelix: 0.273, Turn: 0.303, Sheet: 0.242
Instability Index19.155
Aromaticity0

Similar Structure Search

Candidates based on structure

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