Basic Information

IDDRAMP02321
SequenceNWRKILGQIASVGAGLLGSLLAGYE
Length25
NameGrammistin Pp3 (Group III grammistin; fish, chordates, animals)
SourcePogonoperca punctata (Clown grouper) (Bearded grouper)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.Fish. Sci. 2001 Oct;67:928-933.]Gram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=50 µg/ml), Staphylococcus aureus IAM 1011 (MIC=50 µg/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=50 µg/ml), Escherichia coli JCM 1649 (MIC>50 µg/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=25 µg/ml), Salmonella typhimurium S1 (MIC>50 µg/ml), S. putrefaciens IAM 1509 (MIC=12.5 µg/ml), Vibrio anguillarum NCIBM 829 (MIC=50 µg/ml), Vibrio parahaemolyticus (MIC=50 µg/ml).
Hemolytic Activity[Ref.Fish. Sci. 2001 Oct;67:928-933.]75 HU/mg hemolytic activity against horse erythrocytes(1 HU was defined as the amount of peptide causing 50% hemolysis)
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P69847
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed IDPubMed ID is not available

Physicochemical Properties

Residues25
SequenceNWRKILGQIASVGAGLLGSLLAGYE
Molecular Weight2586.981
Grand Average of Hydropathy0.516
Isoelectric Point8.59
Charge at pH 7.40.556
Secondary StructureHelix: 0.400, Turn: 0.320, Sheet: 0.360
Instability Index-3.444
Aromaticity0.08

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