Basic Information

IDDRAMP02380
SequenceNWRKILGKIAKVAAGLLGSMLAGYQV
Length26
NameGrammistin Gs C (Group III grammistin; soapfish, chordates, animals)
SourceGrammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=6.25 µg/ml), Staphylococcus aureus IAM 1011 (MIC=12.5 µg/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=25 µg/ml), Escherichia coli JCM 1649 (MIC=12.5 µg/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=6.25 µg/ml), Salmonella typhimurium S1 (MIC=12.5 µg/ml), S. putrefaciens IAM 1509 (MIC=6.25 µg/ml), Vibrio anguillarum NCIBM 829 (MIC=12.5 µg/ml), Vibrio parahaemolyticus (MIC=25 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P69846
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID15777955

Physicochemical Properties

Residues26
SequenceNWRKILGKIAKVAAGLLGSMLAGYQV
Molecular Weight2758.331
Grand Average of Hydropathy0.535
Isoelectric Point10.462
Charge at pH 7.43.547
Secondary StructureHelix: 0.385, Turn: 0.231, Sheet: 0.346
Instability Index-6.192
Aromaticity0.077

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Candidates based on structure

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