Basic Information

IDDRAMP02423
SequenceDFGCARGMIFVCMRRCARMYPGSTGYCQGFRCMCDTMIPIRRPPFIMG
Length48
NameHlMS-defensin (Ticks, Arthropods, animals)
SourceHaemaphysalis longicornis (Tick)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=18.8 µg/ml), Bacillus licheniformis (MIC=9.4 µg/ml);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=28.1 µg/ml), Pseudomonas aeruginosa ATCC27853 (MIC=37.5 µg/ml), Serratia rubidaea (MIC=28.1 µg/ml), Psychrobacter faecalis (MIC=2.3 µg/ml).##Fungi: Candida albicans ATCC2002 (MIC=18.8 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22033149

Physicochemical Properties

Residues48
SequenceDFGCARGMIFVCMRRCARMYPGSTGYCQGFRCMCDTMIPIRRPPFIMG
Molecular Weight5504.665
Grand Average of Hydropathy0.162
Isoelectric Point9.214
Charge at pH 7.44.406
Secondary StructureHelix: 0.229, Turn: 0.229, Sheet: 0.167
Instability Index57.046
Aromaticity0.125

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