Basic Information

IDDRAMP03028
SequenceIDWKKLLDAAKQIL
Length14
NamePolybia-MP1
SourcePolybia paulista
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.29075946] Gram-positive bacterium: Bacillus subtilis (MIC=12.5μM), Staphylococcus aureus (MIC=18.8μM);##Gram-negative bacterium:Escherichia coli (MIC=75μM), Shigella dysenteriae (MIC=75μM), Klebsiella pneumoniae (MIC=37.5μM)
Hemolytic Activity[Ref.29075946] <1% hemolysis at 12.5μM, 3.2% hemolysis at 25μM against human red blood cells.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/Branchedstapled peptide
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29075946

Physicochemical Properties

Residues14
SequenceIDWKKLLDAAKQIL
Molecular Weight1654.99
Grand Average of Hydropathy0.064
Isoelectric Point8.498
Charge at pH 7.40.551
Secondary StructureHelix: 0.429, Turn: 0.000, Sheet: 0.357
Instability Index33.864
Aromaticity0.071

Similar Structure Search

Candidates based on structure

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