Basic Information

IDDRAMP03062
SequenceVTGELKRDKRVTCNIGEWVCVAHCNSKSKKSGYCSRGVCYCTN
Length43
NameDefensin-A (DefA; GmDefA; Insects, animals)
SourceGlossina morsitans morsitans (Savannah tsetse fly)
ActivityAntimicrobial, Antibacterial, Anti-Gram-, Antiprotozoal
PathogenProtozoan: Procyclic trypanosomes (IC50=10 µM).##Gram-negative bacteria: Sodalis (IC50=2 µM),Escherichia coli DH5α (IC50=0.2 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q8WTD4
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID11592981, 11886771

Physicochemical Properties

Residues43
SequenceVTGELKRDKRVTCNIGEWVCVAHCNSKSKKSGYCSRGVCYCTN
Molecular Weight4784.484
Grand Average of Hydropathy-0.5
Isoelectric Point9.079
Charge at pH 7.44.398
Secondary StructureHelix: 0.233, Turn: 0.256, Sheet: 0.093
Instability Index17.188
Aromaticity0.07

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