Basic Information

IDDRAMP03198
SequenceACYCRIPACFAGERRYGTCFYLGRVWAFCC
Length30
NameAlpha-defensin PhD-4 (primates, mammals, animals)
SourcePapio hamadryas (Hamadryas baboon)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenIn low salt conditions: Gram-negative bacterium: E. coli ML35p (MIC=2.4 µM),;##Gram-positive bacteria: Listeria monocytogenes EGD (MIC=2.2 µM), methicillin-resistant S. aureus ATCC 33591 (MIC=3.5 µM).##Fungi: Candida albicans 820 (MIC=3.9 µM).##At high physiological salt concentrations: E. coli ML35p (MIC=7.1 µM), L. monocytogenes EGD (MIC=1.8 µM), S. aureus ATCC 33591 (MIC>50 µM), Candida albicans 820 (MIC>50 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P86724
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID20155756

Physicochemical Properties

Residues30
SequenceACYCRIPACFAGERRYGTCFYLGRVWAFCC
Molecular Weight3487.111
Grand Average of Hydropathy0.443
Isoelectric Point8.678
Charge at pH 7.42.454
Secondary StructureHelix: 0.333, Turn: 0.133, Sheet: 0.200
Instability Index58.684
Aromaticity0.233

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