Basic Information

IDDRAMP03222
SequenceGFGALFKFLAKKVAKTVAKQAAKQGAKYVVNKQME
Length35
NameM-ctenitoxin-Cs1a (M-CNTX-Cs1a; Cupiennin-1a; spiders, Arthropods, animals)
SourceCupiennius salei (Wandering spider)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Insecticidal
Pathogen[Ref.11792701]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=0.31-0.63 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=0.31-0.63 µM);##Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=0.31-0.63 µM), Enterococcus faecalis ATCC 29212 (MIC=2.50-5.00 µM).
Hemolytic Activity[Ref.11792701]EC50=24.4 μM against human red blood cells.
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P83619
PDB 2K38
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID11792701, 17319697

Physicochemical Properties

Residues35
SequenceGFGALFKFLAKKVAKTVAKQAAKQGAKYVVNKQME
Molecular Weight3799.531
Grand Average of Hydropathy-0.131
Isoelectric Point10.301
Charge at pH 7.46.538
Secondary StructureHelix: 0.286, Turn: 0.114, Sheet: 0.314
Instability Index25.171
Aromaticity0.114

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