Basic Information

IDDRAMP03750
SequenceIFGAIAGLLKNIF
Length13
NameVenom antimicrobial peptide-6 (Meucin-13; NDBP-5; Arthropods, animals)
SourceMesobuthus eupeus (Lesser Asian scorpion)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.19088182]Gram-positive bacteria: Bacillus sp. DM-1 (MIC=2 µM), Micrococcus luteus (MIC=2.9 µM), Bacillus megaterium (MIC=0.25 µM);##Gram-negative bacteria: Agrobacterium tumefaciens (MIC=11.8 µM), Escherichia coli (MIC=7.90 µM), Shewanella oneidensis (MIC=6.20 µM), Stenotrophomonus sp. YC-1 (MIC=6.20 µM);##Fungi: Beauveria spp. (MIC=14.1 µM), Neurospora crassa (MIC=18.3 µM), Candida albicans (MIC=42.8 µM), Saccharomyces cerevisiae (MIC=18.3 µM).
Hemolytic Activity[Ref.19088182]37.7% hemolytic activity at 6.25 M, 59.2% hemolytic activity at 12.5 M against rabbit red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot E4VP07, E4VP35
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19088182

Physicochemical Properties

Residues13
SequenceIFGAIAGLLKNIF
Molecular Weight1376.684
Grand Average of Hydropathy1.7
Isoelectric Point8.75
Charge at pH 7.40.555
Secondary StructureHelix: 0.538, Turn: 0.231, Sheet: 0.308
Instability Index29.969
Aromaticity0.154

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Candidates based on structure

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