Basic Information

IDDRAMP18188
SequenceGILGKLWEGFKSIV
Length14
NamePantinin-1 (Non-disulfide-bridged peptide 4.20, NDBP-4.20, Non-disulfide-bridged peptide 5.21, ND
SourcePandinus imperator (Emperor scorpion)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.23624072]Gram-positive bacteria: S.aureus (MIC=8 μM), B.magaterium (MIC=32 μM), M.luteus (MIC=32 μM ), VRE (MIC=28 μM), MRSA (MIC=14 μM);##Gram-negative bacteria: E.coli (MIC=62 μM), P.putida (MIC >87 μM), K.oxytoca (MIC >87 μM), E.cloacae (MIC=76 μM), S.enterica (MIC=72 μM);##Fungus: C.tropicalis (MIC=16 μM).
Hemolytic Activity[Ref.23624072]0% hemolytic activity at 16 μM, 0% hemolytic activity at 32 μM, 20% hemolytic activity at 64 μM against human red bood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot R4JNJ5
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID23624072, 24184590

Physicochemical Properties

Residues14
SequenceGILGKLWEGFKSIV
Molecular Weight1546.85
Grand Average of Hydropathy0.671
Isoelectric Point8.591
Charge at pH 7.40.554
Secondary StructureHelix: 0.500, Turn: 0.286, Sheet: 0.214
Instability Index4.964
Aromaticity0.143

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.