| ID | DRAMP20932 |
|---|---|
| Sequence | GILGKLWEGVKSIF |
| Length | 14 |
| Name | Hp1404 |
| Source | Heterometrus petersii |
| Activity | Antimicrobial, Antibacterial, Anti-Gram- |
| Pathogen | [Ref.29379033] Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC=12.5 μM), Pseudomonas aeruginosa 138 (MIC=12.5 μM), Pseudomonas aeruginosa 431 (MIC=12.5 μM), Pseudomonas aeruginosa 434 (MIC=12.5 μM), Pseudomonas aeruginosa 557 (MIC=6.25 μM), Pseudomonas aeruginosa 559 (MIC=25 μM), Pseudomonas aeruginosa 778 (MIC=12.5 μM), Pseudomonas aeruginosa 1034 (MIC=6.25 μM), Pseudomonas aeruginosa 1162 (MIC=12.5 μM), Pseudomonas aeruginosa 3290 (MIC=12.5 μM), Pseudomonas aeruginosa 3399 (MIC=6.25 μM), Pseudomonas aeruginosa 3543 (MIC=6.25 μM), Pseudomonas aeruginosa 3592 (MIC=6.25 μM), Pseudomonas aeruginosa 3904 (MIC=6.25 μM), Pseudomonas aeruginosa 4007 (MIC=25 μM), Pseudomonas aeruginosa 4319 (MIC=12.5 μM), Pseudomonas aeruginosa 4891 (MIC=6.25 μM), Pseudomonas aeruginosa 5018 (MIC=12.5 μM), Pseudomonas aeruginosa 671973 (MIC=3.13 μM) |
| Hemolytic Activity | [Ref.29379033]Hemolysis 2% at 12.5 μM against mouse red blood cell, hemolysis 11% at 25.0 μM against mouse red blood cell, hemolysis 55% at 50.0 μM against mouse red blood cell, hemolysis 92% at 100.0 μM against mouse red blood cell, hemolysis 100% at 200.0 μM against mouse red blood cell |
| Cytotoxicity | [Ref.29379033] The cell survial against HaCaT cells is 85%, 26%, 5% and 6% at peptide concentrations of 25, 50, 100 and 200 μM |
| N-terminal Modification | Free |
| C-terminal Modification | Amidation |
| Linear/Cyclic/Branched | Linear |
| Uniprot | |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 29379033 |
Physicochemical Properties
| Residues | 14 |
|---|---|
| Sequence | GILGKLWEGVKSIF |
| Molecular Weight | 1546.85 |
| Grand Average of Hydropathy | 0.671 |
| Isoelectric Point | 8.591 |
| Charge at pH 7.4 | 0.554 |
| Secondary Structure | Helix: 0.500, Turn: 0.286, Sheet: 0.214 |
| Instability Index | 19.707 |
| Aromaticity | 0.143 |