Basic Information

IDDRAMP03922
SequenceKWKLFKKIGIGAVLKVLTTG
Length20
NameCecropin A (1-8)-melittin (1-12)hybrid peptide
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-negative bacteria: Escherichia coli D21 (MIC=0.4 µM), Pseudomonas aeruginosa OT97 (MIC=0.9 µM);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.3 µM), Bacillus megaterium Bm11 (MIC=0.2 µM), Staphylococcus aureus Cowan 1 (MIC=2 µM), Streptococcus pyogenes (MIC=0.1 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID1733777

Physicochemical Properties

Residues20
SequenceKWKLFKKIGIGAVLKVLTTG
Molecular Weight2200.75
Grand Average of Hydropathy0.52
Isoelectric Point10.602
Charge at pH 7.44.545
Secondary StructureHelix: 0.450, Turn: 0.150, Sheet: 0.200
Instability Index-27.73
Aromaticity0.1

Similar Structure Search

Candidates based on structure

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