Basic Information

IDDRAMP03993
SequenceKKLLKWLKKLL
Length11
NameL5K5W6 (LlKmWn model peptide)
SourceSynthetic construct (De novo design)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=6.3 µg/ml), Staphylococcus aureus ATCC 6538p (MIC=6.3 µg/ml), Staphylococcus epidermis ATCC 12228 (MIC=6.3 µg/ml), Micrococcus luteus ATCC 10240 (MIC=6.3 µg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.5 µg/ml), Shigella dysentariae ATCC 9752 (MIC=6.3 µg/ml), Salmonella typhomurium ATCC 14028 (MIC=25 µg/ml), Klebsiella pneumoniae ATCC 10031 (MIC=6.3 µg/ml), Pseudomonas aeruginosa ATCC 27 853 (MIC=25 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19544481

Physicochemical Properties

Residues11
SequenceKKLLKWLKKLL
Molecular Weight1410.875
Grand Average of Hydropathy-0.127
Isoelectric Point10.602
Charge at pH 7.44.545
Secondary StructureHelix: 0.545, Turn: 0.000, Sheet: 0.455
Instability Index-10.564
Aromaticity0.091

Similar Structure Search

Candidates based on structure

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