| ID | DRAMP04013 |
|---|---|
| Sequence | GLVTGLLKTAGKLLGDLFGSLTG |
| Length | 23 |
| Name | Plasticin ANC KF (analog of natural peptide ANC) |
| Source | Synthetic construct |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
| Pathogen | [Ref.17128968]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=12.5 µM), Bacillus megaterium ATCC 9885 (MIC=12.5 µM);##Gram-negative bacteria: Escherichia coli ATCC 11775 (MIC=25 µM). |
| Hemolytic Activity | [Ref.17128968]22% hemolytic at 50 μM, 48% hemolytic activity at 100 μM against rat red blood cells |
| Cytotoxicity | Not included yet |
| N-terminal Modification | Not included yet |
| C-terminal Modification | Not included yet |
| Linear/Cyclic/Branched | Not included yet |
| Uniprot | |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 17128968 |
Physicochemical Properties
| Residues | 23 |
|---|---|
| Sequence | GLVTGLLKTAGKLLGDLFGSLTG |
| Molecular Weight | 2231.63 |
| Grand Average of Hydropathy | 0.817 |
| Isoelectric Point | 8.591 |
| Charge at pH 7.4 | 0.553 |
| Secondary Structure | Helix: 0.391, Turn: 0.304, Sheet: 0.348 |
| Instability Index | -12.583 |
| Aromaticity | 0.043 |