Basic Information

IDDRAMP01638
SequenceGLWSKIKEAAKAAGKAALNAVTGLVNQGDQPS
Length32
NameDermaseptin-L1 (Frogs, amphibians, animals)
SourceHylomantis lemur (Lemur leaf frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram-, Antifungal
PathogenGram-negative bacterium: Escherichia coli (MIC=8 µM).##Fungi: Batrachochytrium dendrobatidis (MIC>100 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.17561225]Displayed cytotoxic against HepG2 cells(LC50=45μM)
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID17561225

Physicochemical Properties

Residues32
SequenceGLWSKIKEAAKAAGKAALNAVTGLVNQGDQPS
Molecular Weight3194.596
Grand Average of Hydropathy-0.191
Isoelectric Point9.528
Charge at pH 7.41.549
Secondary StructureHelix: 0.219, Turn: 0.281, Sheet: 0.344
Instability Index13.503
Aromaticity0.031

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