Basic Information

IDDRAMP04659
SequenceFKRLKKLFKKIWNWK
Length15
NameHPA3NT3(Derived from HP (2–20))
SourceHelicobacter pylori
ActivityAntimicrobial, Antibacterial, Anti-gram+, Anti-gram-, Antifungal
Pathogen[Ref.19642077] Gram-positive bacteria : Staphylococcus aureus(MIC=4 μM), Bacillus subtilis(MIC=4 μM), Listeria monocytogenes(MIC=22 μM);##Gram-negative bacteria : Escherichia coli(MIC=4 μM), Salmonella typhimurium(MIC=2 μM), Pseudomonas aeruginosa(MIC=2 μM);##Fungi : Candida albicans(MIC=8 μM), Trichosporon beigelli(MIC=2-4 μM)
Hemolytic Activity[Ref.19642077] 32% hemolysis at 50 μM , 46% hemolysis at 100 μM , 70% hemolysis at 200 μM against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22982494, 19642077

Physicochemical Properties

Residues15
SequenceFKRLKKLFKKIWNWK
Molecular Weight2063.578
Grand Average of Hydropathy-1.033
Isoelectric Point11.433
Charge at pH 7.46.542
Secondary StructureHelix: 0.467, Turn: 0.067, Sheet: 0.133
Instability Index-4.64
Aromaticity0.267

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.