Basic Information

IDDRAMP18185
SequenceFLPLFLPKIICVITKKC
Length17
NameJingdongin-1
SourceAmolops jingdongensis (Chinese torrent frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.22828809]Gram-negative bacterium: B.dysenteriae (MIC=35 μg/ml);##Gram-positive bacteria: S.aureus ATCC 2592 (MIC=4.7 μg/ml), B.subtilis ATCC 6633 (MIC=9.38 μg/ml);##Fungus: C.albicans (MIC=18.75 μg/ml)
Hemolytic Activity[Ref.22828809] It exhibits hemolysis of 1.32%, 5.37%, 6.35%, 16.55% at 25 μg/ml, 50 μg/ml, 100 μg/ml, 200 μg/ml against rabbit red blood cells
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization(Cys11 and Cys17).
Linear/Cyclic/BranchedCyclic
Uniprot K7ZGS2
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22828809

Physicochemical Properties

Residues17
SequenceFLPLFLPKIICVITKKC
Molecular Weight1976.577
Grand Average of Hydropathy1.418
Isoelectric Point9.39
Charge at pH 7.42.501
Secondary StructureHelix: 0.529, Turn: 0.118, Sheet: 0.176
Instability Index22.641
Aromaticity0.118

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