Basic Information

IDDRAMP01253
SequenceFLPLLLAGLPLKLCFLFKKC
Length20
NameDybowskin-6 (Frogs, amphibians, animals)
SourceRana dybowskii (Korea brown frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Antifungal
PathogenGram-positive bacteria: Micrococcus luteus ATCC4698 (MIC=6.25 µg/ml), Staphylococcus aureus KCTC3881 (MIC=12.5 µg/ml), Bacillus subtilis ATCC6633 (MIC=50 µg/ml), Staphylococcus epidermidis ATCC12228 (MIC=50 µg/ml).##Yeast: Candida albicans (MIC=50 µg/ml).
Hemolytic Activity[Ref:17698251] It has 59.39% hemolytic activity at 100 μg/ml against huamn red blood cells
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys14 and Cys20)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID17698251

Physicochemical Properties

Residues20
SequenceFLPLLLAGLPLKLCFLFKKC
Molecular Weight2277.96
Grand Average of Hydropathy1.515
Isoelectric Point9.39
Charge at pH 7.42.501
Secondary StructureHelix: 0.550, Turn: 0.150, Sheet: 0.450
Instability Index12.755
Aromaticity0.15

Similar Structure Search

Candidates based on structure

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