Basic Information

IDDRAMP18666
SequenceGLGSVFGRLARILGRVIPKV
Length20
NameP1 (Pilosulin-1 1-20; Ant, insects, arthropods, invertebrates, animals)
SourceMyrmecia pilosula (Jumper ant)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anitifungal, Anti-Gram-
Pathogen[Ref.15639237]Gram-positive bacteria: Staphylococcus aureus 710A (MIC=4 μM), Bacillus megaterium BM11 (MIC=2 μM);##Gram-negative bacteria: Escherichia coli ML-35 (MIC=2 μM), Pseudomonas aeruginosa ATCC27853 (MIC=8 μM), Salmonella typhimurium ATCC14028 (MIC=8 μM).##Drug resistant clinical isolates: Staphylococcus simulans 22 (MIC=2 μM), Micrococcus luteus (MIC=0.5 μM), Enterococcus spp. I-11305b (MIC=2 μM), Enterococcus spp. I-11054 (MIC=2 μM), Staphylococcus haemolyticus I-10925 (MIC=2 μM), Staphylococcus epidermidis LT1324 (MIC=2 μM), Staphylococcus aureus 5185 (MIC=2 μM), Staphylococcus aureus I-11574 (MIC=2 μM), Staphylococcus aureus LT1338 (MIC=3 μM), Staphylococcus aureus T1334 (MIC=1.5 μM), Citrobacter freundii I-11090 (MIC=2 μM), Klebsiella pneumoniae I-10910 (MIC=2 μM), Escherichia coli I-11276b (MIC=4 μM), Escherichia coli O-19592 (MIC=2 μM), Stenotrophomonas maltophilia O-16451 (MIC=2 μM), Stenotrophomonas maltophilia I-10717 (MIC=2 μM), Pseudomonas aeruginosa 4991 (MIC=4 μM), Pseudomonas aeruginosa I-10968 (MIC=4 μM), Candida albicans I-11301 (MIC=4 μM).
Hemolytic Activity[Ref.15639237]20% hemolysis at 10μM, 100% hemolysis at 100μM against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q07932
PDB 5X3L
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID15639237

Physicochemical Properties

Residues20
SequenceGLGSVFGRLARILGRVIPKV
Molecular Weight2108.575
Grand Average of Hydropathy0.81
Isoelectric Point12
Charge at pH 7.43.555
Secondary StructureHelix: 0.450, Turn: 0.300, Sheet: 0.200
Instability Index13.445
Aromaticity0.05

Similar Structure Search

Candidates based on structure

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