Basic Information
| ID | DRAMP20890 |
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| Sequence | VYPFCWGGAYAFCKAKLV |
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| Length | 18 |
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| Name | VT18-CAKKLV (VT18 peptide derivative) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+ |
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| Pathogen | [Ref.29277569] Gram-positive bacteria: Streptococcus pneumoniae ATCC 700669 (MIC=58 μg/ml), Streptococcus pneumoniae ATCC 49619 (MIC=90 μg/ml), Streptococcus pneumoniae ATCC 700677 (MIC=72 μg/ml) |
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| Hemolytic Activity | [Ref.29277569] 0.5% hemolysis at 5 μg/ml, 1.0% hemolysis at 10μg/ml, 1.5% hemolysis at 20 μg/ml, 2.0% hemolysis at 50 μg/ml, 3.8% hemolysis at 100 μg/ml, 4.5% hemolysis at 250 μg/ml, 6.8% hemolysis at 500 μg/ml against human red blood cells |
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| Cytotoxicity | [Ref.29277569] The cell viability of NL-20 normal lung cell line is not affected (<20%) below 50 μg/ml.## The cell viability of NL-20 is 86%, 48%, 19% and 11% at peptide concentrations of 50, 100, 250 and 500 μg/ml. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 29277569 |
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