Basic Information

IDDRAMP20937
SequenceHRVKRNGFRKFMRRLKKFFAGG
Length22
NamePb-CATH3
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.28630199] Gram-positive bacteria: B. cereus ATCC 10876 (MIC=32 μg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=8 μg/ml), S. typhimurium ATCC 14028 (MIC=2 μg/ml);##Clinical isolates: Escherichia coli (4.7 μg/ml), K. pneumoniae (1.18 μg/ml)
Hemolytic Activity[Ref.28630199]0% hemolysis at 8 μg/ml, 1.7 ± 0.5% hemolysis at 16 μg/ml, 3.1 ± 0.5% hemolysis at 32 μg/ml, 4.0 ± 0.2% hemolysis at 64 μg/ml against chicken red blood cells
Cytotoxicity[Ref.28630199] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID28630199

Physicochemical Properties

Residues22
SequenceHRVKRNGFRKFMRRLKKFFAGG
Molecular Weight2737.287
Grand Average of Hydropathy-1.05
Isoelectric Point12
Charge at pH 7.48.584
Secondary StructureHelix: 0.273, Turn: 0.182, Sheet: 0.136
Instability Index46.191
Aromaticity0.182

Similar Structure Search

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