Basic Information
| ID | DRAMP21121 |
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| Sequence | KRIVkLILKWLR |
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| Length | 12 |
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| Name | KR-12-a5 (5-(D)K) (Derived from LL-37) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.28525841] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=8 μM), Staphylococcus epidermidis(KCTC 1917)(MIC=4 μM), Staphylococcus aureus(KCTC1621)(MIC=2 μM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=4 μM), Pseudomonas aeruginosa(KCTC 1637)(MIC=8 μM), Salmonella typhimurium(KCTC 1926)(MIC=2 μM) |
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| Hemolytic Activity | [Ref.28525841] MHC10=79 μM against human red blood cells |
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| Cytotoxicity | [Ref.28525841] The cell viability of mouse macrophage RAW264.7 cells is 100%, 103.4%, 116.6%, 118.9%, 115.1%, 107.9% and 105.7% at peptide concentrations of 0, 4, 8, 16, 32, 64, 128 and 256 μM |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 28525841 |
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