Basic Information
| ID | DRAMP21122 |
|---|
| Sequence | KRIVKlILKWLR |
|---|
| Length | 12 |
|---|
| Name | KR-12-a5 (6-(D)L) (Derived from LL-37) |
|---|
| Source | Synthetic construct |
|---|
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
|---|
| Pathogen | [Ref.28525841] Gram-positive bacteria : Bacillus subtilis(KCTC 3068)(MIC=4 μM), Staphylococcus epidermidis(KCTC 1917)(MIC=4 μM), Staphylococcus aureus(KCTC1621)(MIC=2 μM);##Gram-negative bacteria : Escherichia coli(KCTC 1682)(MIC=4 μM), Pseudomonas aeruginosa(KCTC 1637)(MIC=4 μM), Salmonella typhimurium(KCTC 1926)(MIC=2 μM) |
|---|
| Hemolytic Activity | [Ref.28525841] MHC10=202 μM against human red blood cells |
|---|
| Cytotoxicity | [Ref.28525841] The cell viability of mouse macrophage RAW264.7 cells is 100%, 101.9%, 118.9%, 107.5%, 111.3%, 110.6% and 110.6% at peptide concentrations of 0, 4, 8, 16, 32, 64, 128 and 256 μM |
|---|
| N-terminal Modification | Free |
|---|
| C-terminal Modification | Amidation |
|---|
| Linear/Cyclic/Branched | Linear |
|---|
| Uniprot |
|
|---|
| PDB |
|
|---|
| 3D View | |
|---|
| PDB Download | Download PDB Predicted by Alphafold2 |
|---|
| PubMed ID | 28525841 |
|---|
