Basic Information

IDDRAMP21379
SequenceNAMRGAKRVWRHI
Length13
NameSP7 (De Novo Synthesis)
Sourcesynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram-
Pathogen[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC >100 µg/mL)
Hemolytic Activity[Ref.31163671] 10% hemolysis at >100 μg/mL against human blood cells.
Cytotoxicity[Ref.31163671] The cell viability of Hepa 1-6 induced by SP7 is 91.9%, 95.9%, 103.4%, 94.6%, 93.9% and 91.2% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 μg/mL.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID31163671

Physicochemical Properties

Residues13
SequenceNAMRGAKRVWRHI
Molecular Weight1594.888
Grand Average of Hydropathy-0.862
Isoelectric Point12
Charge at pH 7.43.591
Secondary StructureHelix: 0.231, Turn: 0.154, Sheet: 0.231
Instability Index64.062
Aromaticity0.077

Similar Structure Search

Candidates based on structure

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