Basic Information

IDDRAMP21399
SequenceRRYGTCIYQGRLWAF
Length15
NamePep-H (Human, mammals, animals)
SourceHomo sapiens (Human)
ActivityAntimicrobial, Antibacterial, Anti-Gram+
Pathogen[Ref.31133658] Gram-positive bacteria:M.tb H37Rv (MIC=10 μg/ml)
Hemolytic Activity[Ref.31133658] 2.7% hemolysis at 1μg/ml, 5% hemolysis at 5μg/ml, 6% hemolysis at 50μg/ml, 8% hemolysis at 100 μg/ml against human blood cells.
Cytotoxicity[Ref.31133658] The cell viability of MDMs induced by Pep-H is 94.2%, 91.5%, 90.4%, 88.0% and 84.1% at peptide concentrations of 1, 5, 25, 50, 100 μg/mL
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID31133658

Physicochemical Properties

Residues15
SequenceRRYGTCIYQGRLWAF
Molecular Weight1890.174
Grand Average of Hydropathy-0.44
Isoelectric Point10.046
Charge at pH 7.42.528
Secondary StructureHelix: 0.400, Turn: 0.133, Sheet: 0.133
Instability Index36.94
Aromaticity0.267

Similar Structure Search

Candidates based on structure

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