Basic Information

IDDRAMP29122
SequenceLNLRALLAVARRIL
Length14
NameMastoparan-C [K4,11,12R]
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-
Pathogen[Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=4 µM); Bacillus subtilis ATCC 23857(MIC=4 µM);##Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=4 µM); Pseudomonas aeruginosa ATCC 9027(MIC=8 µM); Klebsiella pneumoniae ATCC 700603(MIC=16 µM).
Hemolytic Activity[Ref.33285267]10% hemolysis against mouse erythrocytes at 32 µM,87% hemolysis against mouse erythrocytes at 256 µM.
Cytotoxicity[Ref.33285267]No cytotoxicity information found.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot P01516
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID33285267

Physicochemical Properties

Residues14
SequenceLNLRALLAVARRIL
Molecular Weight1591.985
Grand Average of Hydropathy1.15
Isoelectric Point12
Charge at pH 7.42.557
Secondary StructureHelix: 0.500, Turn: 0.071, Sheet: 0.571
Instability Index77.714
Aromaticity0

Similar Structure Search

Candidates based on structure

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