Basic Information

IDDRAMP29137
SequenceGLLGKLLKIAAKVGKKLL
Length18
NameXT-7 [P5K,S15K,N16K]
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.18554256]Gram-negative bacteria:Escherichia coli ATCC 25726(MIC=25 µM);##Gram-positive bactria:Staphylococcus aureus ATCC 25923(MIC=3 µM);##Fungi:Candida albicans ATCC 900280(MIC=3 µM);##Cancer:human hepatoma‐derived cells HepG2 (LC50=5 µM).
Hemolytic Activity[Ref.18554256]Hemolysis against human erythrocytes (LC50=25 µM).
Cytotoxicity[Ref.18554256]No cytotoxicity information found.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot P84381
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID18554256

Physicochemical Properties

Residues18
SequenceGLLGKLLKIAAKVGKKLL
Molecular Weight1863.421
Grand Average of Hydropathy0.8
Isoelectric Point10.602
Charge at pH 7.44.545
Secondary StructureHelix: 0.444, Turn: 0.167, Sheet: 0.444
Instability Index-28.289
Aromaticity0

Similar Structure Search

Candidates based on structure

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