Basic Information
| ID | DRAMP00337 |
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| Sequence | AIPCGESCVWIPCISTVIGCSCSNKVCYR |
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| Length | 29 |
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| Name | ChaC8 (Chassatide C8; uncyclotides; Plant defensin) |
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| Source | Chassalia chartacea |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | Gram-negative bacterium: Escherichia coli (MIC=6.6 µM);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 µM), Staphylococcus epidermidis (MIC>80 µM). |
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| Hemolytic Activity | [Ref.22467870] HD50 = 25.5 μM against human red blood cells (Type A). Kalata B1 and melittin were used as the positive control. |
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| Cytotoxicity | [Ref.22467870] IC50 = 1.0 μM targeting on HeLa cells. Kalata B1 was used as the positive control. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 22467870 |
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