Basic Information

IDDRAMP00770
SequenceGEYCGESCYLIPCFTPGCYCVSRQCVNKN
Length29
NameChaC10 (Chassatide C10; Plant defensin)
SourceChassalia chartacea
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer
PathogenGram-negative bacterium: Escherichia coli (MIC>80 µM);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 µM), Staphylococcus epidermidis (MIC>80 µM).
Hemolytic Activity[Ref.22467870] HD50>25 µM against human type A red blood cells.
Cytotoxicity[Ref.22467870] Cytotoxicity: HeLa cells (IC50=5.0 µM).
N-terminal ModificationNo specific N-terminal
C-terminal ModificationNo specific C-terminal
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22467870

Physicochemical Properties

Residues29
SequenceGEYCGESCYLIPCFTPGCYCVSRQCVNKN
Molecular Weight3237.707
Grand Average of Hydropathy-0.069
Isoelectric Point6.101
Charge at pH 7.4-0.597
Secondary StructureHelix: 0.276, Turn: 0.310, Sheet: 0.103
Instability Index32.393
Aromaticity0.138

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