Basic Information

IDDRAMP01643
SequenceGLWSTIKQKGKEAAIAAAKAAGQAALGAL
Length29
NameDermaseptin-5 (DShypo05, DS 01; Frogs, amphibians, animals)
SourcePhyllomedusa hypochondrialis (Orange-legged leaf frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiprotozoal
Pathogen[Ref.8306981]Gram-negative bacterium: Escherichia coli (MIC=6.4 µM);##Gram-positive bacterium: Staphylococcus aureus (MIC=3.2 µM).
Hemolytic Activity[Ref:8306981]Non-hemolytic activity against rabbit red blood cells.
Cytotoxicity[Ref.12379643]No cytotoxicity information found##[Ref.17442605]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot P84600
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID12379643, 17442605

Physicochemical Properties

Residues29
SequenceGLWSTIKQKGKEAAIAAAKAAGQAALGAL
Molecular Weight2795.24
Grand Average of Hydropathy0.286
Isoelectric Point10.001
Charge at pH 7.42.549
Secondary StructureHelix: 0.207, Turn: 0.172, Sheet: 0.483
Instability Index14.262
Aromaticity0.034

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.