Basic Information

IDDRAMP01748
SequenceFFPIVGKRLYGLL
Length13
NameTemporin-AJ8 (Frogs, amphibians, animals)
SourceAmolops jingdongensis (torrent frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.22828809] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=70 μg/ml), B. dysenteriae(MIC=18.75 μg/ml) ;## Gram-positive bacteria: Staphylococcus aureus ATCC 2592(MIC=4.7 μg/ml), Bacillus subtilis ATCC 6633(MIC=9.38 μg/ml);## Yeast: Candida albicans ATCC 2002(MIC=37.5 μg/ml).
Hemolytic Activity[Ref.22828809] 1.79% hemolysis at 25μg/ml, 5.22% hemolysis at 50μg/ml, 7.92% hemolysis at 100μg/ml, 10.85% hemolysis at 200μg/ml against rabbit red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot K7Z903
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22828809

Physicochemical Properties

Residues13
SequenceFFPIVGKRLYGLL
Molecular Weight1522.873
Grand Average of Hydropathy1.046
Isoelectric Point9.994
Charge at pH 7.41.552
Secondary StructureHelix: 0.615, Turn: 0.231, Sheet: 0.231
Instability Index23
Aromaticity0.231

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