Basic Information

IDDRAMP02065
SequenceSFLDTLKNLAISAAKGAGQSVLSTLSCKLSETC
Length33
NameBrevinin-2-OR5 (Frogs, amphibians, animals)
SourceOdorrana rotodora (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli ATCC 25922 (MIC=13.2 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=6.6 µg/ml).##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=6.6 µg/ml).##Fungi: Candida albicans (MIC=6.6 µg/ml).
Hemolytic Activity[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 μg/mL.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys27 and Cys33)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues33
SequenceSFLDTLKNLAISAAKGAGQSVLSTLSCKLSETC
Molecular Weight3357.849
Grand Average of Hydropathy0.397
Isoelectric Point7.767
Charge at pH 7.40.198
Secondary StructureHelix: 0.273, Turn: 0.273, Sheet: 0.333
Instability Index23.882
Aromaticity0.03

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