Basic Information

IDDRAMP02069
SequenceSFLSTFKELAINAAKNAGQSLLHTLSCKLDKTC
Length33
NameBrevinin-2-OR10 (Frogs, amphibians, animals)
SourceOdorrana rotodora (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15.8 µg/ml), Bacillus pyocyaneus CMCCB 10104 (MIC=7.9 µg/ml).##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=7.9 µg/ml).##Fungi: Candida albicans (MIC=15.8 µg/ml).
Hemolytic Activity[Ref.22029824] It shows no hemolytic activity against human red blood cells at the concentration of 50 μg/mL.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys27 and Cys33)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues33
SequenceSFLSTFKELAINAAKNAGQSLLHTLSCKLDKTC
Molecular Weight3554.1
Grand Average of Hydropathy0.094
Isoelectric Point8.802
Charge at pH 7.41.232
Secondary StructureHelix: 0.273, Turn: 0.212, Sheet: 0.333
Instability Index24.645
Aromaticity0.061

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