Basic Information

IDDRAMP01526
SequenceSIRDKIKTIAIDLAKSAGTGVLKTLICKLNKSC
Length33
NameRugosin-RN5 (Frogs, amphibians, animals)
SourceRana nigrovittata
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=15.00 µg/ml), Staphylococcus aureus ATCC43300 (MRSA) (MIC=12.50 µg/ml), Bacillus subtilis (MIC=18.75 µg/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=25.00 µg/ml).##Yeast: Candida albicans ATCC2002 (MIC=18.75 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.19778602]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys27 and Cys33)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19778602

Physicochemical Properties

Residues33
SequenceSIRDKIKTIAIDLAKSAGTGVLKTLICKLNKSC
Molecular Weight3503.227
Grand Average of Hydropathy0.261
Isoelectric Point9.786
Charge at pH 7.44.19
Secondary StructureHelix: 0.303, Turn: 0.182, Sheet: 0.212
Instability Index8.742
Aromaticity0

Similar Structure Search

Candidates based on structure

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