Basic Information

IDDRAMP02290
SequenceFLGPIIKIATGILPTAICKFLKKC
Length24
NameGaegurin-RN5 (Frogs, amphibians, animals)
SourceRana nigrovittata
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.19778602]Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=3.75 µg/ml), Staphylococcus aureus ATCC43300 (MIC=62.50 µg/ml), Bacillus subtilis (MIC=4.69 µg/ml);##Gram-negative bacterium: Escherichia coli ML-35P (MIC=37.50 µg/ml);##Yeast: Candida albicans ATCC2002 (MIC=4.69 µg/ml).
Hemolytic Activity[Ref.19778602] It has no detectable hemolysis at the concentration up to 100 μg/ml
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys18 and Cys24)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19778602

Physicochemical Properties

Residues24
SequenceFLGPIIKIATGILPTAICKFLKKC
Molecular Weight2589.295
Grand Average of Hydropathy1.129
Isoelectric Point9.701
Charge at pH 7.43.498
Secondary StructureHelix: 0.417, Turn: 0.167, Sheet: 0.208
Instability Index7.946
Aromaticity0.083

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