Basic Information

IDDRAMP02378
SequenceWWRELLKKLAFTAAGHLGSVLAAKQSGW
Length28
NameGrammistin Gs A (Group III grammistin; soapfish, chordates, animals)
SourceGrammistes sexlineatus (Sixline soapfish) (Golden stripe soapfish)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Bacillus subtilis IAM 1026 (MIC=25 µg/ml), Staphylococcus aureus IAM 1011 (MIC=12.5 µg/ml);##Gram-negative bacteria: Aeromonas salmonicida NCIBM 1102 (MIC=25 µg/ml), Escherichia coli JCM 1649 (MIC=50 µg/ml), P. dameselae subsp. Piscicida Sp 9587 (MIC=25 µg/ml), Salmonella typhimurium S1 (MIC>50 µg/ml), S. putrefaciens IAM 1509 (MIC=6.25 µg/ml), Vibrio anguillarum NCIBM 829 (MIC=50 µg/ml), Vibrio parahaemolyticus (MIC=50 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P69845
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID15777955

Physicochemical Properties

Residues28
SequenceWWRELLKKLAFTAAGHLGSVLAAKQSGW
Molecular Weight3125.625
Grand Average of Hydropathy0.086
Isoelectric Point10.29
Charge at pH 7.42.588
Secondary StructureHelix: 0.357, Turn: 0.179, Sheet: 0.393
Instability Index32.121
Aromaticity0.143

Similar Structure Search

Candidates based on structure

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