Basic Information

IDDRAMP02609
SequenceRLGDILQKAREKIEGGLKKLVQKIKDFFGKFAPRTES
Length37
NameCjaRL-37 (cathelicidin; primates, mammals, animals)
SourcePlatyrrhini (New World monkeys)
ActivityAntimicrobial, Antibacterial, Antifungal
PathogenIn 20% TSB in SPB medium: Escherichia coli (MIC=4 µM), Pseudomonas aeruginosa (MIC>32 µM); Staphylococcus aureus (MIC=32 µM), Enterococcus faecalis (MIC>32 µM).##In 20% SAB in SPB medium: Candida albicans (MIC>32 µM). In 5% SAB in SPB Candida albicans (MIC>32 µM). In 20% SAB in PIL Candida albicans (MIC>32 µM).##In 5% TSB in SPB Escherichia coli (MIC=1 µM), Pseudomonas aeruginosa (MIC=2 µM), Staphylococcus aureus (MIC=8-16 µM).##In 20% TSB in PIL Escherichia coli (MIC>32 µM), Pseudomonas aeruginosa (MIC>32 µM); Staphylococcus aureus (MIC=16 µM), Enterococcus faecalis (MIC>32 µM).##In 50% MH in SPB medium Escherichia coli (MIC>32 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16720578

Physicochemical Properties

Residues37
SequenceRLGDILQKAREKIEGGLKKLVQKIKDFFGKFAPRTES
Molecular Weight4245.967
Grand Average of Hydropathy-0.678
Isoelectric Point10.116
Charge at pH 7.44.544
Secondary StructureHelix: 0.297, Turn: 0.162, Sheet: 0.243
Instability Index36.73
Aromaticity0.081

Similar Structure Search

Candidates based on structure

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