Basic Information

IDDRAMP20956
SequenceALGDFFRKSKEKIGKEFKRIVQRIKDFLRNLAKRHHGYKRKFHLEY
Length46
NameAL32-P113
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.29859288] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=66.6 ± 28.8 μg/mL);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=41.6 ± 14.4 μM), Extended-spectrum beta-lactamase producing Escherichia coli (MIC=41.6 ± 14.4 μg/mL), New Delhi metallo-bata-lactamase-1 producing Acinetobacter baumannii (MIC=20.8 ± 7.2 μg/mL);##Fungi: Candida albicans ATCC 90028 (MIC=166.6 ± 57.7 μg/mL)
Hemolytic Activity[Ref.29859288] Hemolysis 10.4 ± 2.2% at 500 μg/ml against human red blood cells
Cytotoxicity[Ref.29859288] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29859288

Physicochemical Properties

Residues46
SequenceALGDFFRKSKEKIGKEFKRIVQRIKDFLRNLAKRHHGYKRKFHLEY
Molecular Weight5733.683
Grand Average of Hydropathy-1.093
Isoelectric Point10.596
Charge at pH 7.49.694
Secondary StructureHelix: 0.326, Turn: 0.109, Sheet: 0.196
Instability Index24.072
Aromaticity0.152

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