Basic Information

IDDRAMP03186
SequenceSFGLCRLRRGFCARGRCRFPSIPIGRCSRFVQCCRRVW
Length38
NameSpheniscin-2 (Sphe-2; penguin avian beta-defensin 103b; birds ,animals)
SourceAptenodytes patagonicus (King penguin)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.14525994]Gram-positive bacteria: Micrococcus luteus (MIC=1.5-3.0 µM), Bacillus subtilis (MIC=0.8-1.5 µM), Bacillus cereus ATCC 11778 (MIC=3-6 µM), Bacillus megaterium (MIC=0.4-0.8 µM), Staphylococcus aureus (MIC=1.5-3.0 µM), Staphylococcus saprophyticus (MIC=1.5-3.0 µM), Staphylococcus haemolyticus (MIC=1.5-3.0 µM), Nocardia asteroides (MIC=0.8-1.5 µM), Aerococcus viridans (MIC=0.4-0.8 µM), Listeria monocytogenes (MIC=6-12 µM);##Gram-negative bacteria: Escherichia coli SBS 363 (MIC=0.8-1.5 µM), Escherichia coli 1106 (MIC=1.5-3.0 µM), Salmonella typhimurium (MIC=6-12 µM), Klebsiella pneumoniae (MIC=50-100 µM), Pseudomonas aeruginosa ATCC 82118 (MIC=6-12 µM), Vibrio metschnikovii NCTC 8483 (MIC=25-50 µM), Vibrio anguillarum ATCC 19264 (MIC=25-50 µM);##Fungi: Candida glabrata (MIC>100 µM), Candida albicans IHEM 8060 (MIC=50-100 µM), Candida tropicalis (MIC=1.5-3.0 µM), Neurospora crassa (MIC=3-6 µM),Aspergillus fumigatus (MIC=3-6 µM).
Hemolytic ActivityIt has hemolytic activity
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot P83430
PDB 1UT3
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID14525994, 15123713

Physicochemical Properties

Residues38
SequenceSFGLCRLRRGFCARGRCRFPSIPIGRCSRFVQCCRRVW
Molecular Weight4507.402
Grand Average of Hydropathy-0.095
Isoelectric Point11.635
Charge at pH 7.49.106
Secondary StructureHelix: 0.289, Turn: 0.237, Sheet: 0.079
Instability Index52.947
Aromaticity0.132

Similar Structure Search

Candidates based on structure

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