Basic Information

IDDRAMP03278
SequenceIWLTALKFLGKHAAKHLAKQQLSKL
Length25
NameM-lycotoxin-Hc1a (M-LCTX-Hc1a; Lycotoxin I; spiders, Arthropods, animals)
SourceHogna carolinensis (Carolina wolf spider) (Lycosa carolinensis)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Bacillus thuringiensis subsp. Israelensis (MIC<5.0 µM);##Gram-negative bacteria: Escherichia coli D31 (MIC=10-20 µM), Escherichia coli DH5 (MIC=80-150 µM).##Fungi: Candida glabrata ATCC 2001 (MIC=100-150 µM), Candida albicans clinical isolate (MIC=100-200 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P61507
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID9442044, 18098329

Physicochemical Properties

Residues25
SequenceIWLTALKFLGKHAAKHLAKQQLSKL
Molecular Weight2844.445
Grand Average of Hydropathy0.064
Isoelectric Point10.602
Charge at pH 7.44.618
Secondary StructureHelix: 0.360, Turn: 0.080, Sheet: 0.400
Instability Index21.508
Aromaticity0.08

Similar Structure Search

Candidates based on structure

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