Basic Information

IDDRAMP03304
SequenceQIVDCWETWSRCTKWSQGGTGTLWKSCNDRCKELGRKRGQCEEKPSRCPLSKKAWTCICY
Length60
NameHydramacin-1 (Hm-1; annelida, animals)
SourceHydra vulgaris (Hydra) (Hydra attenuata)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-negative bacteria: Acinetobacter baumannii ATCC 19606 (MBC=7.1 µM), Burkholderia cepacia ATCC 25416 (MBC>14.3 μM),Burkholderia cepacia ATCC 17759 (MBC>14.3 μM), B. cepacia LMG 16654 (MBC>14.3 μM), Citrobacter freundii NCTC 9750 (MBC=7.1 μM), C. freundii C7 (MBC=0.9 μM), Enterobacter cloacae Va11263/03 (MBC>14.3 μM), E. cloacae Va12270/03 (MBC=0.9 μM), Escherichia coli ATCC 25922 (MBC=0.9 μM), Klebsiella pneumoniae ATCC 13883 (MBC=0.9 μM), Klebsiella oxytoca ATCC 13182 (MBC=0.9 μM), Proteus mirabilis ATCC 21100 (MBC=14.3 μM), P. vulgaris ATCC 13315 (MBC>14.3 μM), Providencia rettgeri NCTC 7475 (MBC>14.3 μM), Pseudomonas aeruginosa NCTC 11446 (MBC>14.3 μM), Salmonella typhimurium 10003442 (MBC=0.9 μM), S. typhimurium 10003630 (MBC=0.9 μM), Serratia marcescens Mero060/148 (MBC>14.3 µM), S. marcescens Mero103/013 (MBC>14.3 μM), S. marcescens NCTC 10211 (MBC>14.3 μM), Yersinia enterocolitica NCTC 11176 (MBC=0.9 µM).##Multi-resistant Gram-negative bacteria: Escherichia coli Co 86 ESBL (MBC=3.6 μM), Klebsiella oxytoca ESBL 33 (MBC=7.1 µM), K. oxytoca ESBL 37 (MBC=3.6 μM), Klebsiella pneumoniae ATCC 700603 (MBC=3.6 μM).##Gram-positive bacteria: Staphylococcus aureus ATCC 6538 (MBC>14.3 μM), Staphylococcus haemolyticus ATCC 29970 (MBC=1.8 μM), Streptococcus pyogenes ATCC 12344 (MBC>14.3 μM).##Multi-resistant Gram-positive bacteria: Staphylococcus aureus ATCC 33593 (MRSA) (MBC>14.3 μM), Enterococcus faecalis ATCC 51299 (MBC>14.3 μM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot B3RFR8
PDB 2K35
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19013190, 19019828

Physicochemical Properties

Residues60
SequenceQIVDCWETWSRCTKWSQGGTGTLWKSCNDRCKELGRKRGQCEEKPSRCPLSKKAWTCICY
Molecular Weight7017.027
Grand Average of Hydropathy-0.948
Isoelectric Point9.048
Charge at pH 7.45.347
Secondary StructureHelix: 0.200, Turn: 0.217, Sheet: 0.133
Instability Index39.207
Aromaticity0.1

Similar Structure Search

Candidates based on structure

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