| ID | DRAMP03570 |
|---|---|
| Sequence | LLGDFFRKSKEKIGKEFKRIVQR |
| Length | 23 |
| Name | LL-23 (Derived from LL-37) |
| Source | Homo sapiens (Human sweat) |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
| Pathogen | Gram-negative bacterium: Escherichia coli DC2 (MIC=9 µM);##Gram-positive bacteria: Staphylococcus aureus mprF (presence of carbonate) (MIC=3 µM), S. aureu mprF (absence of carbonate) (MIC=24 µM). |
| Hemolytic Activity | No hemolysis information or data found in the reference(s) presented in this entry |
| Cytotoxicity | Not included yet |
| N-terminal Modification | Not included yet |
| C-terminal Modification | Not included yet |
| Linear/Cyclic/Branched | Not included yet |
| Uniprot | P49913, Q71SN9 |
| PDB | 2LMF |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 17012259, 22185690 |
Physicochemical Properties
| Residues | 23 |
|---|---|
| Sequence | LLGDFFRKSKEKIGKEFKRIVQR |
| Molecular Weight | 2823.341 |
| Grand Average of Hydropathy | -0.843 |
| Isoelectric Point | 10.549 |
| Charge at pH 7.4 | 4.548 |
| Secondary Structure | Helix: 0.348, Turn: 0.130, Sheet: 0.174 |
| Instability Index | 2.852 |
| Aromaticity | 0.13 |