Basic Information

IDDRAMP18662
SequenceLLAGLAANFLPKIFCKITRKC
Length21
NameBrevinin 21 (Brevinin-1E truncated peptide 21; Frogs, amphibians, animals)
SourceRana esculenta
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anitifungal, Anti-Gram-
Pathogen[Ref.9748603]Gram-positive bacteria: Staphylococcus aureus ATCC 6538 (MIC=12.5 μg/ml), Methicillin resistant Staphylococcus aureus (MIC=25 μg/ml), Micrococcus luteus ATCC 9341 (MIC=6.25 μg/ml);##Gram-negative bacteria:Escherichia coli ATCC 2592 (MIC=12.5 μg/ml), Pseudomonas aeruginosa ATCC 9027 (MIC=12.5 μg/ml);##Fungus: Candida albicans ATCC 36232 (MIC=6.25 μg/ml).
Hemolytic Activity[Ref.9748603]HD50=77 μg/ml(oxidized); HD50=110 μg/ml(reduced) against mouse red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID9748603

Physicochemical Properties

Residues21
SequenceLLAGLAANFLPKIFCKITRKC
Molecular Weight2320.904
Grand Average of Hydropathy0.848
Isoelectric Point9.851
Charge at pH 7.43.501
Secondary StructureHelix: 0.381, Turn: 0.143, Sheet: 0.333
Instability Index3.452
Aromaticity0.095

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