Basic Information

IDDRAMP20803
SequenceFFRNLWKGAKAAFRAGHAAWRA
Length22
Namemoronecidin-like peptide
SourceHippocampus comes
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.30039186] Gram-positive bacteria:Staphylococcus aureus ATCC 25923 (MIC=3.12 μg/ml),Staphylococcus epidermidis ATCC 1435 (MIC=1.56 μg/ml),Staphylococcus aureus MRSA (MIC=3.12 μg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.25 μg/ml), Pseudomonas aeruginosa ATCC10662 (MIC=50 μg/ml),Acinetobacter baumannii clinical isolate (MIC=6.25 μg/ml);##Fungi:Candida albicans clinical isolate (MIC=6.25 μg/ml), Candida tropicalis clinical isolate (MIC=6.25 μg/ml)
Hemolytic Activity[Ref.30039186] 50% hemolysis at 87.5μg/ml,25% hemolysis at 50μg/ml,60% hemolysis at 100μg/ml against human red cells
Cytotoxicity[Ref.30039186] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID30039186

Physicochemical Properties

Residues22
SequenceFFRNLWKGAKAAFRAGHAAWRA
Molecular Weight2532.906
Grand Average of Hydropathy-0.264
Isoelectric Point12
Charge at pH 7.44.589
Secondary StructureHelix: 0.273, Turn: 0.136, Sheet: 0.364
Instability Index18.2
Aromaticity0.227

Similar Structure Search

Candidates based on structure

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