Basic Information

IDDRAMP02358
SequenceGWGSIFKHGRHAAKHIGHAAVNHYL
Length25
NamePleurocidin-like peptide WF4 (NRC-6; fish, chordates, animals)
SourcePseudopleuronectes americanus (Winter flounder 4-1.1)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Aeromonas salmonicida 99-1 (MIC=4 µg/ml), A. salmonicida 97-4 (MIC=4 µg/ml), Salmonella enterica serovar Typhimurium MS7953s (MIC=4 µg/ml), S. enterica serovar Typhimurium 14028s (MIC=64 µg/ml), Pseudomonas aeruginosa K799 (MIC=16 µg/ml), Pseudomonas aeruginosa Z61 (MIC=4 µg/ml), Escherichia coli CGSC 4908 (MIC=4 µg/ml), E. coli UB1005 (MIC=4 µg/ml), E. coli DC2 (MIC=2 µg/ml);##Gram-positive bacteria: Staphylococcus epidermidis C621 (MIC>64 µg/ml), Staphylococcus aureus (MRSA) C623 (MIC=32 µg/ml).##Yeast: Candida albicans C627 (MIC=32 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q90ZX8, Q90ZX9
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID12878506, 11113283

Physicochemical Properties

Residues25
SequenceGWGSIFKHGRHAAKHIGHAAVNHYL
Molecular Weight2765.099
Grand Average of Hydropathy-0.376
Isoelectric Point10.29
Charge at pH 7.42.733
Secondary StructureHelix: 0.280, Turn: 0.240, Sheet: 0.200
Instability Index43.084
Aromaticity0.12

Similar Structure Search

Candidates based on structure

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