Basic Information

IDDRAMP20969
SequenceKLLKHKLLVTLA
Length12
NameHJH-1 (bovine cathelicidin, cattle, ruminant, mammals, animals)
SourceBovine
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.30110916]Gram-positive bacteria : Staphylococcus aureus ATCC29213 (MIC=25 μg/ml), Clinical Staphylococcus aureus (MIC=25 μg/ml), ;##Gram-negative bacteria : Escherichia coli ATCC25922 (MIC=12.5 μg/ml), Clinical Escherichia coli (MIC=25 μg/ml), Salmonella pullorum CVCC3533 (MIC=6.25 μg/ml), Clinical Salmonella (MIC=6.25 μg/ml);##Fungi : Candida albicans ATCC 90029 (MIC=50 μg/ml)
Hemolytic Activity[Ref.30110916] 8% hemolysis at 50 μg/ml , 12% hemolysis at 100 μg/ml , 16% hemolysis at 200 μg/ml , 17% hemolysis at 300 μg/ml , 18% hemolysis at 400 μg/ml against rabbit red blood cells
Cytotoxicity[Ref.30110916] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID30110916

Physicochemical Properties

Residues12
SequenceKLLKHKLLVTLA
Molecular Weight1376.772
Grand Average of Hydropathy0.783
Isoelectric Point10.302
Charge at pH 7.42.587
Secondary StructureHelix: 0.500, Turn: 0.000, Sheet: 0.500
Instability Index0.6
Aromaticity0

Similar Structure Search

Candidates based on structure

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