Basic Information
| ID | DRAMP20972 |
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| Sequence | KLLRHRLLVTLA |
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| Length | 12 |
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| Name | JH-1 (Derived from P3) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.25753638] Gram-positive bacteria : Staphylococcus aureus ATCC29213 (MIC=6.25 μg/ml), Clinical Staphylococcus aureus (MIC=6.25 μg/ml), ;##Gram-negative bacteria : Escherichia coli ATCC25922 (MIC=3.125 μg/ml), Clinical Escherichia coli (MIC=6.25 μg/ml), Pseudomonas aeruginosa clinical strain (MIC=12.5 μg/ml) |
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| Hemolytic Activity | [Ref.25753638] 2% hemolysis at 50 μg/ml , 2.5% hemolysis at 100 μg/ml , 2.5% hemolysis at 200 μg/ml , 3% hemolysis at 300 μg/ml , 4% hemolysis at 400 μg/ml against human red blood cells |
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| Cytotoxicity | [Ref.25753638] The cell viability of HaCaT cell lines is 84% and 80% at peptide concentrations of 200 and 400 μg/ml. In Kunming mice, the LD50 of JH-1 is 94 mg/kg for i.p. injection, while the LD50 of PMB(served as a control) is 50 mg/kg. No mortality |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 25753638 |
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